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Cymbalta Dosage eMedTV Sitemap Don't have a HealthSavvy account yet? Click Here to sign up!A person's dosage of Cymbalta is often determined by the medical condition being treated and existing medical conditions, among other things. The recommended starting dose for treating neuropathic pain or generalized anxiety disorder is 60 mg once daily. The recommended starting dose for treating depression is 20 mg twice daily, 30 mg twice daily, or 60 mg once daily. Cymbalta (duloxetine) Drug Information by MedicineNet.com Fibromyalgia Friendly Exercises Slideshow Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for treating depression, anxiety disorder and pain associated with diabetic peripheral neuropathy or fibromyalgia. Other drugs in this class include milnacipran (Savella), venlafaxine (Effexor), and desvenlafaxine (Pristiq). Duloxetine affects neurotransmitters, the chemicals that nerves within the brain make and release in order to communicate with one another.